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How Cardio Affects Your Brain, According to Science

Love it or hate it, there's no denying exercise is good for your body. Regular aerobic exercise (a.k.a. cardio) has been linked to a lower risk of heart disease, diabetes and cancer. But it's also good for your brain, helping you clear the mental cobwebs and potentially boosting productivity.

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Mounting evidence shows that those cerebral effects aren't just short term. Increased blood flow to the brain, among other factors, has a physiological impact that can improve cognitive function, according to the World Health Organization's (WHO) 2019 Guidelines on Risk Reduction of Cognitive Decline and Dementia.

If ever there was a time to start exercising, it's now!

Benefits of Aerobic Exercise for Brain Health

The idea that exercise strengthens the mind is nothing new. An article published back in 1887 in The Boston Medical and Surgical Journal states that exercise "may be made to contribute to brain growth, and to the symmetrical development of the mental faculties."

Fast forward 130 years and researchers still aren't exactly sure how these benefits work — but they're learning. Cynthia Green, PhD, president of Total Brain Health and assistant clinical professor in the department of psychiatry at Mount Sinai School of Medicine, says it's likely a combination of factors, including better blood flow to the brain and better management of risk factors such as hypertension and excess weight.

Here are a few other factors that science says make a big difference:

1. May Reduce Brain Inflammation

Widespread chronic inflammation in the body contributes to the development of diseases like arthritis, diabetes, heart disease and cancer. It also affects the brain and can lead to compromised cognitive function, mild cognitive impairment and Alzheimer's.

But aerobic exercise is a powerful tool for suppressing inflammation in the body. A March 2017 study published in Brain, Behavior, and Immunity found that just 20 minutes of moderate intensity aerobic exercise decreased markers of inflammation in 47 healthy volunteers.

And when researchers of a September 2015 study published in Journal of Inflammation looked at the effects of aerobic exercise on sleep-deprived rats, they found that regular aerobic exercise decreased pro-inflammatory responses in the rats' hippocampal region — the area of the brain responsible for memory, learning and emotion.

The researchers concluded that exercise has a neuroprotective effect that can counter hippocampal inflammation due to sleep deprivation. For those who experience sleep deprivation, that's good news. However, it doesn't mean it's OK to get less sleep as long as you exercise. Sleep plays a major role in memory processing and brain plasticity, according to the authors of the study.

2. Can Boost Brain Function

The brain uses about 50 percent of the glucose energy in the body, and it relies on glucose metabolism for optimal functioning. Abnormalities in glucose metabolism in the brain can affect a number of neurological and psychiatric disorders, including neurodegenerative diseases like Alzheimer's.

Regular moderate-intensity exercise can also improve glucose metabolism in the brain, according to results of a June 2017 study published in Journal of Alzheimer's Disease. The study involved 93 late middle-age adults at high genetic risk of the disease. Researchers measured the daily activity of participants using accelerometers that detected light, moderate and strenuous activity, and then analyzed the data.

Researchers found that moderate-intensity activity was associated with improved glucose metabolism. In addition, those who engaged in moderate activity for more than 68 minutes each day showed greater results than those who spent less time exercising.

3. Helps Your Brain Process Information

Comprising more than 50 percent of the brain, white matter connects the different regions of the brain so they can communicate. Neuronal fibers covered in electrical insulation called myelin make this communication fast and efficient, so you can process information quickly and learn new things faster.

When the formation of new myelin — called myelination — slows or stops, it affects cognitive function. It's also been associated with psychological disorders including depression and schizophrenia.

The good news is that myelin production can be stimulated through physical exercise. A December 2017 study in Journal of Alzheimer's Disease examined the correlation between cardiorespiratory fitness and white matter integrity in 81 older adults, some with mild cognitive impairment, or MCI. MCI results in a slight reduction in memory and thinking skills, and it affects 15 to 20 percent of adults over the age of 65, according to the Alzheimer's Association.

Participants were assessed using VO2 aerobic testing — the gold standard for measuring cardiovascular fitness — and also completed memory and reasoning tests. Researchers examined their brains using a specialized brain scan to assess white matter fiber integrity and found that higher levels of cardiovascular fitness correlated with increased white matter integrity and better cognitive performance among the participants with mild impairment.

4. May Improve Memory and Learning

The WHO 2019 guidelines recommend exercise as an intervention that can help reduce a person's risk of cognitive decline. Aerobic exercise, specifically, has been shown to have an even more positive effect than other forms of fitness.

The hippocampus is the center of learning, memory and emotion in the brain, and it's prone to shrinking with age. A loss of volume in the hippocampus can result in compromised verbal memory and learning ability. A February 2015 study in the British Journal of Sports Medicine revealed that regular aerobic exercise appears to increase hippocampal volume in women, who are more at risk of hippocampal shrinkage than men.

In the study, 86 females between the ages of 70 and 80 with probable mild cognitive impairment were randomly assigned to a six-week program of aerobic training, resistance training or balance and tone training. MRI scans before and after the program showed significantly improved left, right and total hippocampal volumes in the aerobic training group.

Similarly, a small April 2019 study published in the Journal of the International Neuropsychological Society tested the effects of aerobic training on cognitive function. This study didn't assess hippocampal volume specifically, but rather, tested the impact of exercise on semantic memory — the long term memory your brain develops by learning, rather than personal experience.

The test subjects were split into a cycling and control group. After a 30-minute workout (or rest for control), both groups were given a memory test. The researchers found greater brain activation with the post-exercise group, rather than those that did not work out.

5. Helps Promote Healthy Brain Aging

Like everything else in your body, your brain is subject to the negative effects of aging. But aerobic exercise can help with that too! A January 2020 study published in the ​Mayo Clinic Proceedings​ reported on the link between cardiovascular exercise and decelerated brain aging and cognitive decline.

Of the more than 2,000 adults who participated, those who did cardio regularly were able to preserve more of their gray matter and total brain volume than those who didn't. Your brain's gray matter is particularly important in facilitating various motor and cognitive functions, including muscle control, memory and decision making.

These findings don't just apply to young people who've been exercising for a while. "Another important feature of the study is that these results may apply to older adults, as well," Ronald Petersen, MD, a Mayo Clinic neurologist and study author said in a press release. "There is good evidence for the value of exercise in midlife, but it is encouraging that there can be positive effects on the brain in later life as well."

So it's never too late to start exercising and reaping the brain-boosting benefits!

Who Can Benefit from Aerobic Exercise?

"Everyone!" says Dr. Green. "We all have brains and should take good care of them at every age." Even children's brains benefit from aerobic exercise, according to research published in August 2014 in Frontiers in Human Neuroscience. The study results showed that children with a higher level of aerobic fitness had white matter that was more compact and fibrous, characteristics indicative of a healthy brain.

Most people associate cognitive decline with old age, but the truth is that brains start to age as soon as the end of puberty, according to professor of psychology and neuroscience at Ohio State University Gary L. Wenck, PhD, on Psychology Today. More conservative estimates point to the 20s, 30s and 40s, when different aspects of cognitive ability peak and then begin to decline.

"Brain health should be a priority for all, as we now know dementia is a disease that takes 20 years in the making. It is not a disease that just turns on when you reach 65, 70 or 80 years old," says Teresa Liu-Ambrose, PhD, a Canadian research chair in physical activity, mobility and cognitive health.

So, the earlier the better.

It's also never too late to begin an aerobic exercise program, in light of the studies showing improvements in brain matter and cognitive impairment — in those already impaired — with an increase in cardiovascular fitness. Although it can be harder to start exercising as an older adult, the payoff will be worth the effort.

What Type of Aerobic Exercise Is Best for Brain Health?

"Studies where people are randomized to exercise programs show that moderate-intensity aerobic exercise and resistance training helps to maintain memory and thinking abilities related to decision making, planning multi-tasking," says Dr. Liu-Ambrose. "As well, these studies show that both types of exercise training have direct impact on both brain structure and function."

Moderate-intensity exercise includes activities such as brisk-walking, biking, swimming, rowing, doing aerobics or aerobic dance, jumping rope and hiking. At a moderate intensity, your heart is beating fast and you're breaking a sweat, but you can still carry on a basic conversation.

According to Dr. Green, complex ideomotor activities may have added benefit. Those are activities that require you to think and move at the same time, such as patterned dancing or skills-based sports like tennis.

No matter what type of exercise you do, consistency is key. "My personal perspective on brain health is akin to saving for retirement or a rainy day," says Dr. Liu-Ambrose. "I want to build reserve for my brain by doing good things for it every day — regular physical activity, try to eat a balanced diet, protect my sleep — which will likely allow my brain to be more resilient to the effects of aging and perhaps even disease."

How Much Exercise Do You Need for Brain Health?

A June 2018 review of research in Neurology Clinical Practice analyzed the results of 98 studies examining exercise and cognition in older adults. According to these findings, if you exercised for 30 minutes a day, you would notice statistically significant results in about three and a half months. You can cut that in half by exercising for 60 minutes a day.

"While more research is needed regarding dose, current recommendations are moderate intensity — so exercising with some effort — of both aerobic and resistance training. Specifically, 150 minutes of moderate aerobic exercise plus two to three sessions of resistance training," Dr. Liu-Ambrose says.

She also says that in addition to meeting the exercise requirements, people should spend less time in sedentary behaviors, such as sitting and lying down. "There is emerging evidence that sedentary behavior may be associated with impaired cognitive function. Thus, in addition to getting your daily walks in and lifting some weight, take frequent breaks from sitting throughout the day," Dr. Liu-Ambrose says.

How to Get Started With Aerobic Exercise

Starting an exercise routine can seem complex, but it can be as simple as going for a brisk daily 30-minute walk. The key is to just start doing something — anything that's moderate intensity — and not worry too much right now about what it is.

When you're ready, break up your walks with periods of jogging. If jogging isn't for you, dust off your bicycle or join a gym and ride a stationary bike while you read or watch TV. Try a new aerobics class or join a running or walking club. Whatever you do just remember: All exercise helps improve brain health and combat cognitive impairment.


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